Yes, I find twist throttles easier for long distance - but if you have a thumb throttle ( I found riding quads), if you put your hand/ thumb right over.
The major complaint riders have against the thumb throttle is fatigue, especially when riding for extended periods of time. Riders generally experience less.
One that came to mind was replacing the thumb throttle. If I experience thumb fatigue on the KFX, I cannot imagine how my wife feels.